My hotkeys tend to be this:
1: Primary weapon
2: Poison
3: Secondary weapon
4: My best healing spell
5-8: Various spells that suit my needs at the time
I am contemplating picking up Enhanced Hotkeys again to give me even more hotkeys, but for now, I'm doing fine with the standard 8.
Also, a new addition to my own load order has been
Less Annoying Magic Experience, which aims to rebalance Oblivion's magic to make it less irritating to use and correct several shortcomings in the ways certain vanilla spells worked. Here's a few noteworthy tidbits:
- Duration of many buffs and debuffs have been significantly improved (x4). No more casting three buffs in a row and the first one is already disappearing! Very powerful buffs / debuffs like Invisibility and Paralyze aren't affected.
Example: the Apprentice rank premade Soul Trap spell has had its duration increased to 80 seconds from 20 seconds so that you no longer have to fret about the spell effect dying while in the middle of a big battle when you have other things on your mind, like staying alive.
- Summons can be killed with Dispel effect.
It is very useful, and has already allowed for a notable increase in my spellcasting. Also, most of the more "out there" features I know you don't like are optional, so I would recommend taking a look at this one.