Most of my melee characters go for Azura's star. Combined with a self-enchanted weapon including Soul Trap, the combo feeds itself. None of the weapon artifacts can match one you've made for yourself.
But pure mages can't see the point in having the Star. They don't use weapons, and when they enchant clothing for defence, it stays at maximum strength for ever. Black/Grand soul gems or Sigil Stones are enough. They don't use the Skeleton key either, preferring to use the various Open spells. They might use some of the rings and amulets that are considered Artifacts, such as Namira's. Staves - sometimes, as they're all a bit quirky.
Thieves pick a lot of locks, so they're divided among the ones who like the Skeleton Key for removing the tedium, and the ones who like to practice, and don't get it. The melee characters place this as second choice after Azura's Star, as they won't have the skill/spells to do without it.
Clark likes the Escutcheon of Chorrol. It's not Daedric, but it's unique, and gives him the Reflect Damage even when he's casting spells, just by being equipped. With a ring or two and an amulet, all he has to worry about is arrows! He's a bit of a pacifist, and likes the idea of the enemies hurting themselves.
The Ring of Khajiiti gets occasional use by many of my characters. Sometimes high chameleon is the only answer to psychic guards!
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Mods for The Elder Scrolls single-player games, and I play ESO.
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