Yeah, I feel the vibe has certainly changed. It is no longer has that Fallout 3 level of humor. I enjoyed 'the bombs have fallen and there is rubble everywhere, but don't worry, life goes on.' Now it feels like a fast shooter with the whole settlement and trading thing going on in the background.
I will say though the Ghouls do not feel or look as scary, but they are very terrifying in combat. Most enemies that tend not to focus on your follower (Ghouls and Mirelurks, so far for me) rush at you very quickly and scare the crap at out you when they charge.
All over I will say the combat feels great. Low level enemies like the basic Raider and Super Mutant are bloody tough now. Yesterday I was attack by 2 simple Super Mutants, bloody hell, I had to switch to the Mini Gun just to finish them off.
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I agree with comments about the MQ. I have always thought that if Beth will not allow the character to see the MQ from an evil perspective then they should just drop the whole idea. Playing a 'hero' MQ all the time is completely stupid in the modern world. We like our characters to be grey, not some knight in shining armor.
The story writing has gone down hill since Emil has played a larger role in the company. Todd is trusting the wrong man with the forming of the story lines.
And to show you just how controlled things are, I read that if you do not follow your spouse up the hill and run off in another direction the Chinese drop the nuke straight away!
I realize that there is no other way to do it but it just shows you that if the lore says the bomb hits at before 10, don't worry Todd says, we can make it 9-30 as well.
