At the risk of double posting as the above post was me also before I got this account, I thought i would list a few features for the curious as I've been obsessively watching update videos haha.
Yes, there are no NPCs. Trading, RP etc will be done with other players. I'm hoping in the future there will be private servers so people can make RP servers.
Although raiders are gone, we have a new enemy called the scorched. These are almost feral ghouls who still have the capacity for firearm combat.
There are strict, and cool IMO, measures to tackle briefing from other players. This includes that players can't be killed by others until they reach level 5. And even then, you can't be killed easily unless you specifically engage in a PVP duel. The first few shots from a griefer does very minimal damage, giving players a chance to escape.
The only microtransactions will be cosmetics. And even then those same cosmetics can be earned in game.
Public servers will only have 24 people. So that in a world 4x the size of FO4 means a very rare chance of bumping into people.
I will edit this once I find out more