One would imagine it would be a classic Fallout story of a Vault opening up for the first time and sending people out to scout around. Or the even classicer Fallout story of a Vault kicking someone out to find a water chip or some other macguffin. TBH, that would be a good starting point for a story that would have the character(s) traveling around and discovering the world for the first time. It would be convenient from a story telling point of view, because that way the audience can learn how the new world works at the same pace as the characters.
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