Archive Invalidation is only relevant to BSA archives - files with .bsa extension. Some mods come with them, and of course Oblivion itself and the DLCs have all their resources stored in BSA archives.
Mod managers only change the load order of mod modules - the ESP files, they don't do anything for BSA. Or at least that's the theory. Oblivion engine itself is supposedly deciding on the load order of the BSA archives that correspond to the mods you're using. SkyBSA is supposed to alter that order. Note that SkyBSA is a mod for Oblivion, it is NOT a mod manager, not an external tool like BOSS or Wrye Bash or whatever. It's a DLL mod that changes the behaviour of the Oblivion engine with respect to loading resources.
So this all only has to do with resources, not with the mods themselves, so it has no bearing on crashes. Missing resources don't normally make the game crash, they just show as great big yellow question marks or diamonds or something. In my case when using SkyBSA, some resources seemed to be loaded in the wrong order or double up, which was extremely weird. But it didn't make the game crash.
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"What is life's greatest illusion?" "Innocence, my brother."
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