Feel free to add to this if you want. So far, I can confirm a couple known issues here.
PC Issues
PC 1. Skyrim was not designed to be played with V-Sync off, and as such framerates beyond 60 FPS can cause major physics bugs and flashing water (accompanied by severe slowdowns). If you wish to not use V-Sync, you will need to limit your FPS using the FPS Capper tool.
ADDENDUM: It has also been confirmed that disabling V-Sync in the game using the iPresentInterval=0 tweak will cause the game calendar to gradually become De-synchronized with the clock, resulting in day turnovers at gradually later and later times. I have checked and it appears that 10 AM is when today becomes tomorrow in my game, and that can cause severe problems for AI schedules relying on a certain day. This cannot be fixed or worked around in any way.
PC 2. Skyrim has an audio bug, and often crashes if you have your audio setting too high. So you have to reduce your computer's sound quality to fix this:
In Windows 7:
Go to Control Panel > Hardware and Sound > Sound
You will see your default sound device. Click it, then click properties.
Go to the Advanced Tab, make sure the default format is set to 44.1Khz 16-bit.
Hit Apply/OK, then run Skyrim.
In Windows Vista:
Go to Control Panel > Sound
Find your default sound device (the one that is checked). Click it, then click properties.
Go to the Advanced Tab, make sure the default format is set to 44.1Khz 16-bit.
Hit Apply/OK, then run Skyrim
PS3 Issues
PS3 1. After approximately 20 to 30 hours of gameplay (to be more precise, once your savegame file size eclipses 6Mb), the game's framerates in exterior environments will drop significantly. There is currently no fix for this, Bethesda will need to address this one themselves.
Xbox 360 Issues
XBX 1. Installing the game to your hard drive introduces a bug where a large number of textures are not scaled properly, and appear at a lower resolution than they should. You can uninstall the game from your drive and play off the disc to prevent this. Patch is pending.
This post has been edited by Thomas Kaira: Nov 20 2011, 04:13 AM